In the world of American football, the name Patrick Mahomes has become synonymous with greatness and victory. With two Super Bowl titles, two Super Bowl MVP awards, and two regular-season MVP honors, Mahomes has turned the impossible into the possible, conquering nearly every challenge and opponent on the field. He holds the second-highest winning percentage of any quarterback in NFL history, a clear testament to his extraordinary talent. Yet, behind this dazzling success story, a surprising and little-known truth has fans and analysts stunned: Patrick Mahomes has never won a regular-season game against one specific team—the Indianapolis Colts.

This bizarre curse isn’t just a minor blip on Mahomes’s otherwise perfect record; it’s a dramatic saga that proves even the greatest legends have their hidden weaknesses. Over his nine-year illustrious career, Mahomes has faced the Indianapolis Colts twice in regular-season play, once in 2019 and again in 2022, and both times, he has tasted bitter defeat. These weren’t just simple losses; they were nail-biting, one-possession contests where the drama was at its peak, and destiny seemed to turn its back on the Kansas City Chiefs’ superstar.

The Fateful Showdowns: The Curse Begins

The first encounter took place in 2019 at the Chiefs’ home, Arrowhead Stadium. At the time, Mahomes and his team were off to a promising start to the season, but the Colts came and spoiled the party. It was a defensive battle, with both teams struggling to find the end zone. The Chiefs offense struggled against a tough Colts defense, while Mahomes tried to find a way to break through. He threw for 321 yards but only had one touchdown pass and one interception. The game produced only two touchdowns in total, with the difference being the steady leg of Adam Vinatieri, the veteran Colts kicker. Vinatieri successfully connected on multiple field goals from 30 yards out, securing a 19-13 victory for Indianapolis. It was a “heartbreaker” for Chiefs Kingdom, who had hoped for an easier victory at home. This defeat was more than just a loss; it was a warning sign, a foreshadowing of an unfortunate fate with the underdog team from Indianapolis.

Three years later, in the 2022 season, the chance for revenge arrived. The Chiefs and Colts faced off again, this time at Lucas Oil Stadium, Indianapolis’s home field. With lessons learned from the 2019 loss, the Chiefs entered the game with high determination. They held a 17-10 lead heading into the fourth quarter, thanks to a touchdown run by Clyde Edwards-Helaire and a field goal from Matt Ammendola. Everything seemed to be under Kansas City’s control. Chiefs fans began to envision Mahomes’s first victory against the Colts. However, Matt Ryan, the Colts’ veteran quarterback, had other plans. With his experience and composure, Ryan orchestrated a game-winning drive in the final minutes. He threw a 12-yard touchdown pass to Jelani Woods, securing a thrilling victory for the Colts. Mahomes again played well, with a combined 583 passing yards and two touchdowns in both games, but it still wasn’t enough to secure a victory. The curse continued to haunt him.

The Strength of the Indianapolis Colts: More Than Just an Opponent

What has made the Indianapolis Colts such a formidable opponent for Patrick Mahomes? Is it a random coincidence, or is there a special factor in how the Colts play against this superstar? Looking back at the past games, it’s clear the Colts always found a way to pressure Mahomes, limiting his mobility and vision. Their defense displayed incredible discipline and ability to read the game, forcing Mahomes to make quick, and sometimes poor, decisions. Additionally, the Colts are not a weak team. Although not always highly rated like the Chiefs, they consistently have the ability to create surprises and win important games.

However, the Colts team Mahomes will face in Week 12 of the 2025 season is not the same team that barely escaped with victories in the past. Indianapolis has undergone a significant rebuilding and development process. They have built a much more dangerous offense, a roster with depth and impressive scoring ability. This season, the Colts have emerged as one of the highest-scoring teams in the league, with a combination of explosive young talent and seasoned veterans. This means Mahomes will face his toughest challenge yet in his attempt to break the curse.

The Fateful Matchup: Week 12 of the 2025 Season

The moment of truth is fast approaching. In Week 12 of the 2025 season, the Kansas City Chiefs will host the Indianapolis Colts at home. This isn’t just another football game; it’s the third and perhaps most important opportunity for Patrick Mahomes to break the curse that has plagued him for nearly a decade.

When the Chiefs opened the betting lines, they were favored by 9.5 points. This is a significant number, reflecting the faith of experts in Mahomes and the Chiefs’ abilities. However, with the powerful rise of the Colts, especially their explosive scoring ability this season, that spread is likely to shrink significantly. The Colts are no longer a team that relies solely on defense and hopes for field goals. They have developed a diverse, flexible, and powerful offensive style that can challenge any defense.

This game will not just be a clash between two teams; it will be a battle of will, talent, and destiny. Can Patrick Mahomes, who has conquered every peak, finally solve the Indianapolis puzzle? Will the third time be the charm, or will the curse continue to haunt him?

Conclusion: A Historic Showdown Awaits

This question is on the mind of every NFL fan. Patrick Mahomes has proven himself to be one of the greatest quarterbacks of all time, but even the greatest have their unexplainable obstacles. The Indianapolis Colts curse is more than just a statistic; it’s an integral part of Mahomes’s career story, a challenge he must overcome to solidify his legendary status.

Chiefs Kingdom is eagerly awaiting this game. They have faith in Mahomes’s abilities but cannot ignore the rising strength of the Colts. This matchup promises to be a historic showdown, a battle not just for a win on the scoreboard but for honor, for a chance to break the curse, and for a new chapter in the career of one of the NFL’s all-time greats.

Let’s wait and see if Patrick Mahomes can finally break free from the shackles of the Indianapolis Colts curse or if history will repeat itself once again. This will undoubtedly be one of the most anticipated games of the 2025 season, an event not to be missed for any football fan.